Ketoconazole

Ketoconazole is a broad-spectrum antifungal agent commonly used in dermatology and personal care formulations. It’s highly effective against fungal and yeast infections of the skin and scalp, including dandruff, seborrheic dermatitis, and tinea-related conditions. Known for its ability to inhibit fungal growth and reduce inflammation, Ketoconazole is a trusted active ingredient in medicated shampoos, creams, and anti-dandruff products.

INCI Name: Ketoconazole

Molecular Formula: C₂₆H₂₈Cl₂N₄O₄

Alternate Names: Nizoral, KCZ

Purity of the Ingredient: 99%

Country of Origin: India

Benefits and Uses

• Treats dandruff and seborrheic dermatitis
• Effective against fungal infections like athlete’s foot and ringworm
• Reduces itchiness, flaking, and inflammation of the scalp
• Used in anti-fungal shampoos, creams, and lotions
• Helps manage acne and fungal folliculitis in some cases

How It Works

• Inhibits ergosterol synthesis, a key component of fungal cell membranes
• Disrupts fungal cell wall integrity, leading to cell death
• Also has mild anti-inflammatory properties that soothe irritated skin
• Effective against Malassezia spp., a major cause of dandruff

pH and Ideal Temperature Range for Best Use

• Optimal pH: 5.0 – 6.5
• Ideal Temperature: Stable below 40°C (104°F); store in a cool, dry place away from direct sunlight

How to Use Ketoconazole for Skincare?

• Use at 1% to 2% in shampoos, scalp treatments, or antifungal creams
• For shampoos: massage into scalp and leave for 3–5 minutes before rinsing
• Can be added to lotion bases for spot treatment on skin
• Combine with soothing agents (like aloe or panthenol) to minimize irritation
• Perform a patch test before use, especially on sensitive skin